The match will be held at the Tuanku Abdul Rahman Stadium in Seremban, Malaysia on Tuesday.
Ali Sabah Adday Al-Qaysi will be assisted by his countryman and an assistant from Malaysia.
Adday Al-Qaysi became a FIFA referee in 2002 and has served as a referee at competitions including the 2018 FIFA World Cup qualifiers, beginning with the preliminary-round match between Palestine and the United Arab Emirates.
Iran tops Group A with 10 points.
The top two in each group reach the 2018 finals with the two third-placed sides meeting over two legs for the chance to face a CONCACAF team in a final playoff for a ticket to Russia.