The general died of wounds suffered in fighting at Mleiha, a key battleground southeast of the capital, making him one of the few top-ranking officers whose deaths have been announced during Syria’s three-year war.
The air defence forces’ headquarters is in Mleiha, a key flashpoint in current fighting around Damascus, AFP reported.
Because the rebels do not have an air force, the forces under Isaac’s command have rarely been deployed for air defence.
For more than a month, the army has been battling to recapture Mleiha, a strategic rebel bastion. It has been under siege for more than a year.