Lawmakers in Strasbourg on Tuesday voted 422-250 for the 59-year-old who will take over as European Commission President in November from the incumbent, Jose Manuel Barroso of Portugal.
The results were announced by the parliament's president, Martin Schulz.
The powerful Brussels-based Commission is in charge of drafting EU legislation, overseeing countries' budgets, policing the EU free trade area and enforcing antitrust action.
Juncker says he will use his 5-year-term to promote policies fostering growth and reducing rampant unemployment in Europe, AP reported.