Paolo Gentiloni is due to travel to Iran on August 4 and 5, the Ministry said on Friday.
Gentiloni had also traveled to Iran earlier this year.
The announcement came as several other European officials have voiced their willingness to pay a visit to Iran after the landmark conclusion of nuclear talks between Tehran and six world powers over Iran's nuclear energy program.
French Foreign Minister Laurent Fabius has also announced a plan to visit Iran next week.
Sigmar Gabriel, Germany’s economy minister and Chancellor Angela Merkel’s deputy, also traveled to Iran on Sunday for high-level economic and trade talks with Iranian officials.
Austrian President Heinz Fischer is also expected in Iran from September 7 to 9.
Also, Radio Poland reported on Friday that Polish Economy Minister Janusz Piechocinski will visit Tehran in September along with a group of businessmen.
Iran and the Group 5+1 (Russia, China, the US, Britain, France and Germany) on July 14 reached a conclusion on a lasting nuclear agreement that would terminate all sanctions imposed on Tehran over its nuclear energy program after coming into force.
The promising prospect of trade with Iran has prompted major European countries to explore the market potential in the populous Middle East nation.