According to Afghan and Pakistani officials, 237 people died in Pakistan and 74 in Afghanistan in the magnitude-7.5 quake, which was centered deep beneath the Hindu Kush mountains in Afghanistan's sparsely populated Badakhshan province bordering Pakistan, Tajikistan and China, The Associated Press reported.
Wais Ahmad Barmak, the Afghan minister for disaster management says 266 people were also injured in Afghanistan.
In Pakistan, authorities say they are struggling to reach remote mountainous quake-affected areas.
The army used helicopters Tuesday to transport supplies to the victims and military engineers were trying to restore communication lines disrupted by landslides triggered by the quake. Thousands of homes have also been damaged.
A major earthquake struck the remote Afghan northeast Monday, killing hundreds of people in Afghanistan and nearby northern Pakistan, and sending shock waves as far as New Delhi.
The death toll could climb in coming days because communications were down in much of the rugged Hindu Kush mountain range where the quake was centered.