The initiative defies Spain's central government, which considers it unconstitutional. A debate preceding the vote is set to begin at 0900 GMT (4 am EST) Monday.
Prime Minister Mariano Rajoy's government has pledged to take legal action against the Barcelona-based parliament if it approves the proposal, the Associated Press reported.
Although Catalan branches of Spain's ruling conservative Popular Party and the Socialist and the Citizens opposition parties filed appeals to halt the vote, Spain's Constitutional Court ruled Thursday that it could go ahead.