"The army gunship helicopters struck positions of Islamic State in Iraq and the Levant (ISIL) affiliated militants in surrounding areas of Achin district on Monday, killing 18 ISIL fighters and destroying one heavy machinegun," the ministry said in a Tuesday statement.
The mountainous district, which is also a known ISIL stronghold, has been the scene of heavy clashes between ISIL militants and security forces since early last year.
In addition, four Taliban militants were killed and their vehicle was destroyed in a similar raid in Yakhchal locality of Gereshk district in the country's southern province of Helmand Monday, according to a separate statement by the ministry, Xinhua reported.
Afghan security forces have pressed on clearing the militants in restive provinces as Taliban militants have been attempting to take territory and consolidate their positions during the winter in the Central Asian country.
The militant groups have yet to make comments.