The strike in the coastal city's Hay Bab Tubrok area damaged a medical facility, a mosque and nearby homes, Nabaa television said, showing images of a crater in a road and smashed vehicles, Reuters reported.
No one immediately claimed responsibility, but Libya is caught in a conflict between two rival factions backed by armed factions on the ground. A UN-backed unity government is trying to bring the factions together.
Airstrikes by unidentified jets often target suspected militant targets, including fighters loyal to Daesh (ISIL) who have been present in Derna and have a stronghold further west along the Mediterranean coast in the city of Sirte.