School officials described the students' injuries as non-life threatening and said they were airlifted to a local hospital for treatment. A doctor at Miami Valley Hospital said the two boys, ages 13 and 14, will fully recover.
Two other students — a 14-year-old girl and 14-year-old boy — suffered shrapnel wounds or were hurt while trying to leave the building, NBC News reported Monday.
Investigators said a shooter, identified as James Austin Hancock, a 14-year-old student at the school, opened fire during lunch in the cafeteria. School officials said he was on the wrestling team.
The suspected gunman was taken into custody and will be charged with two counts of attempted murder, two counts of felonious assault, inducing panic and making terroristic threats, according to the sheriff's office.
"This is a tragic and horrific event that you hope never happens," Butler County Sheriff Richard K. Jones said in a statement Monday.
Officials said the school was on lockdown and students were dismissed just before noon.
Ohio Gov. John Kasich, a Republican running for president, told reporters, "obviously it's a tragedy," but added, "thank God no life was lost."
School and community relations coordinator AJ Huff said the school's emergency training paid off Monday.
"It has been valuable for our teachers and administrators," Huff explained. "When I got the call, I immediately knew what to do, how to handle things, and students knew how to react."