At least 462,000 are suffering from severe acute malnutrition, as food supplies have been disrupted by the devastating war between the Saudi-backed fugitive former government and Houthis, the agency said.
Saada province, a Houthi bastion in the far north, has the world's highest stunting rate among children with eight out of 10 children affected in some areas, it added.
"Malnutrition in Yemen is at an all-time high and increasing," said UNICEF's acting country representative, Meritxell Relano, according to AFP.
"The state of health of children in the Middle East's poorest country has never been as catastrophic as it is today."
At least one child dies every 10 minutes in Yemen because of malnutrition and preventable diseases such as diarrhea and respiratory infections.
"Diseases such as cholera and measles have spread and, with few health facilities functional, such outbreaks are taking a heavy toll on children," Relano said.
In 2016, UNICEF supported the treatment of 215,000 children suffering from severe acute malnutrition and provided more than four million children under the age of five with vitamin supplements.
But relief operations remain hindered by funding shortfalls and limited access to battleground areas.
"We call on parties to the conflict to give us unhindered access to children in need across the country so we are able to deliver nutrition supplies, treat malnourished children and support Yemen's health services," Relano said.