The attack was launched with a car bomb, planted in a street cleaning car that the attackers had stolen a few days earlier, three security sources told Reuters.
After the bomb exploded, attackers fired guns and rocket-propelled grenades at the checkpoint, they added.
There was no immediate claim of responsibility for the attack, which also wounded 13 people, including four civilians. Police found the body of one of the attackers driving the vehicle that exploded.
A terrorist insurgency in the rugged, thinly populated Sinai Peninsula has gained pace since the military toppled President Mohamed Mursi of the Muslim Brotherhood, Egypt's oldest Islamist movement, in mid-2013 following mass protests against his rule.
The group staging the insurgency in Sinai pledged allegiance to Daesh in 2014 and adopted the name Sinai Province. It is blamed for the killing of hundreds of Egyptian soldiers and policemen since then.
In late November Daesh claimed responsibility for an attack on a security checkpoint that killed 15 soldiers.
In its weekly online magazine Al-Nabaa released in November, Daesh urged members to join other branches of the group active in areas like Sinai, Libya, Yemen and West Africa if unable to reach its self-declared "caliphate" in Iraq and Syria.