Francisco Martinez, the regional head of agriculture, environment and rural development for Castilla-La Mancha, said residents from 10 small towns and visitors at a campsite have been relocated, AP reported.
Over 150 firefighters supported by air units were fighting the fire on Saturday. The blaze started on Friday and spread into the National Park of Los Calares del Rio Mundo.
Spain and neighboring Portugal are prone to forest fires during the typically dry and hot summer months.