Several fire engines and an ambulance were deployed at the Movenpick hotel near the Marina district as scores of people gathered outside.
A video of the hotel posted on social media showed thin clouds of smoke wafting around a lower floor, Reuters reported.
The hotel said on its official Twitter account that the fire was "swiftly brought under control and guests and staff were safely evacuated."
Civil defense workers gave the all-clear for people to return inside and there were no reports of injuries.
A blaze shot up the side of a nearby residential tower on Friday, and local media reported that a smaller fire was quickly put out at a neighboring building on Sunday. No injuries were reported in either of those fires.
The series of fires in tall buildings in the UAE has revived questions about the safety of cladding materials used in the Persian Gulf region and beyond.