According to the US Navy, the crash occurred on Wednesday around 4:30 pm. The Navy added that the jet, which was on a training flight, is part of Strike Fighter Squadron 213, known as the Blacklions, CNN reported.
The two-person crew ejected, Navy Cmdr. Mike Kafka said.
Rescue crews recovered both aviators from the water, the Navy said in a tweet. They were taken by ambulance to Lower Keys Medical Center.
The jet crashed on approach to Naval Air Station Key West, and the cause of the crash is under investigation, according to the tweet.