"Air defenses have confronted enemy missiles coming from the sea in the direction of the Latakia city, and intercepted a number of them," the official news agency SANA quoted a military source as saying late on Monday.
The so-called UK-based Syrian Observatory for Human Rights also reported that huge explosions had been heard in the western city.
Local media have reported the large explosions and a power outage in the surrounding area.
It was not immediately known who fired the missiles, which appeared to be targeting “ammunition depots” of Syria's Organization for Technological Industries.
The state-run Al-Ikhbariya TV said the attacks were from the Israeli military targeting the state company.
The attacks came a couple of days after the Syrian missile defense system successfully intercepted and downed Israeli missiles fired at an airport in the capital Damascus.
The Tel Aviv regime has launched the attacks as Syria has managed to recapture many areas across the country from the grip of foreign-backed terrorists.
However, many of those attacks have failed as Syrian defense system has managed to shoot down missiles fired by the Israelis.
Latakia is home to Russia's Hmeimim Air Base, from which Russian fighter jets conduct airstrikes against Daesh terrorists and other foreign-sponsored Takfiri militants.