Branko Ivankovic’s men moved up to second place with 31 points, behind Padideh on goal difference.
Ali Alipour was on target twice in the 31st and 50th minutes and Omid Alishah scored in the 56th minute.
Rouhollah Seifollahi scored a consolation goal just before the final whistle.
Also, Tractor Sazi lost to Foolad 2-1 in its home match.
Reza Mirzaei in the 24th minute and Luciano Pereira Mendes (51st – penalty) scored for the visiting team and Alireza Naghizadeh pulled a goal back for Tractor Sazi in the 76th minute.
Sanat Naft also emerged victorious over Saipa in Abadan.
Moein Abbasian gave Saipa the lead in the 25th minute and Milad Jahani and Mohammadreza Ghobeishavi were on target in the 65th and 82nd minutes.
Sepahan will play Esteghlal Khuzestan on Saturday in Ahvaz.