In the match, held at the Aspire Academy complex in Doha, Qatar, Saeid Karimi and Mohammad Amin Asadi scored for the Reds in the 85th and 90th minutes respectively.
Al Sadd Spaniard star Xavi Hernandez attended the friendly match.
Persepolis, who has won Iran Professional League in the last two seasons, seeks to claim the title for the third time in a row.
The Iranian team is also preparing for the 2019 AFC Champions League.