Amir Ghalenoei’s team could have moved to top of the table but it drew 1-1 with Zob Ahan at the Naghsh-e Jahan Stadium.
Sajjad Shahbazzadeh gave Sepahan the lead in the 34th minute.
Brazilian striker Kiros Stanlley could have extended the lead in the early minutes of the second half but missed a penalty.
With five minutes remaining, Arsalan Motahari leveled the score thanks to a pass from Mohammad Reza Hosseini.
Persepolis sits top of the table with 45 points, followed by Esteghlal, Sepahan and Tractor Sazi with 43 points.