According to Gaza's ministry of health, 16-year-old Fahd al-Astal died on Friday after he was shot in the stomach by the Israeli army east of Khan Younis, Al Jazeera reported.
The ministry added that several others also sustained injuries following the attack.
Hours after the attack, an Israeli warplane launched an airstrike against a position of the Palestinian resistance movement of Hamas in the northern parts of the besieged Gaza strip.
No report of possible damage or casualties caused by the Israeli air raid has been released yet.
Palestinians in Gaza have been holding weekly rallies as part of the Great March of Return since March 30, 2018, calling for an end to the crippling 11-year-long Israeli blockade on the small coastal sliver.
They also underline the right of return for the Palestinians who have been driven out of their homeland by the Israeli regime since 1948.
More than 350 Palestinians in Gaza have been killed and some 26,000 injured since the demonstrations began, mostly by Israeli fire during protests but also by air and tank strikes.
Gaza has been under Israeli siege since June 2007, which has caused a decline in living standards.
Israel has also launched three major wars against the enclave since 2008, killing thousands of Gazans each time and shattering the impoverished territory’s already poor infrastructure.