Rozita Alipour defeated her Turkish rival in -61 kg female kumite semifinals and booked a place in the final match.
Zabiollah Poorshab beat Ivan Kvesic of Croatia in the -84kg male kumite semifinals and will face a Turkish athlete in the final match on Sunday.
In the +84 male kumite, Sajad Ganjzadeh qualified for the final match after defeating his countryman Saleh Abazari.
Nearly 500 athletes from 65 countries are in Chile for the first event of the season.
In addition to launching the year of international karate, the Karate 1-Series A Santiago is the last tournament of the Olympic qualification period to be held in the American continent.