Ali Alipour opened the scoring for Persepolis in the 9th minute in Tehran’s Azadi Stadium.
Alipour’s well-struck shot from just inside the penalty area was well placed into the corner of the net.
Vahid Amiri scored the second goal in the 55th minute.
Naft Masjed Soleyman also earned a valuable victory over Sanat Naft, beating it 2-0 in its home.
Alireza Alizadeh scored in the 41st minute and Omid Singh made it 2-0 in the added time.
Persepolis now has 37 points and sits top of the table.
Second-placed Sepahan remains five points adrift of the top spot.
Tractor is third with 30 points.