In a post on Thursday, the official Twitter account of Ayatollah Khamenei denounced the recent wave of violence against Muslims in India.
“The hearts of Muslims all over the world are grieving over the massacre of Muslims in India,” the post read.
“The govt of India should confront extremist Hindus & their parties & stop the massacre of Muslims in order to prevent India’s isolation from the world of Islam,” it added.
The post ended with the hashtag “Indian Muslims ln Danger”.
Violence erupted in the Indian capital last week, leading to a three-day-long rampage, with Hindu mobs attacking Muslim homes, shops and mosques.
The attacks were carried out on protesters, who have been rallying against a new citizenship law, after the ruling Bharatiya Janata Party (BJP) leader Kapil Mishra threatened peaceful sit-ins would be removed from the streets.
The violence in Delhi killed scores of people.
It was the worst violence in Delhi since 1984, when more than 3,000 Sikh minority were killed following the assassination of then-Prime Minister Indira Gandhi.