Ali Alipour was on target in the 21st minute and Mehdi Abdi scored twice in the 76th and 84th minutes.
With two minutes remaining, Shahriar Moghanloo scored a consolation goal from the penalty spot.
Furthermore, Tractor suffered a 1-0 home defeat to Nassaji, Shahin Bushehr earned a late 2-2 draw against Naft Masjed Soleyman, Sanat Naft defeated Pars Jonoubi 2-0 and Shahr Khodro beat Zob Ahan 2-1.
Persepolis cemented its place on top of the table with 50 points.
Shahr Khodro moved up to second with 38 points.