On Sunday, Persepolis edged Xavi’s Al-Sadd 1-0 thanks to Issa Alekasir’s 88th minute goal.
Persepolis defender Siamak Nemati was sent off in the 90th minute.
Persepolis joins Saudi Arabia's Al-Ahli Saudi FC and Pakhtakor of Uzbekistan in the quarter-finals, with the draw scheduled for Monday.
Al-Nassr and Al-Taawoun SC square off in an all-Saudi affair in the last of the Round of 16 ties later on Sunday.
The quarter-finals matches will be held on Wednesday.