Mohammad Ghazi scored for Mes just seven minutes into the match and Sajad Shahbazzadeh leveled the score in the 45th minute.
Sepahan midfielder Mohammad Reza Hosseini was also on target in the 76th minute.
Sepahan is second behind Gol Gohar due on goal difference.
Wednesday:
*Paykan – Saipa
*Shahr Khodro – Aluminum
Thursday:
*Machine Sazi – Naft Masjed Soleyman
*Zob Ahan – Gol Gohar
*Sanat Naft – Tractor