The Iranian girls won the match 8-0 courtesy of goals from Roghayeh Jalalnasab, Mohaddese Zolfi and Hasti Forouzandeh in the first half.
Zahra Masoumi, Sara Didar, Maryam Mohammadi, Fatemeh Pasandideh and Jalalnasab scored in the second half.
Iran started the campaign with a 3-0 win over host Tajikistan and will play Uzbekistan on Tuesday.
The tournament has brought Tajikistan, Iran, Uzbekistan, Afghanistan and Kyrgyzstan together in a round-robin event in Dushanbe.
The CAFA Junior Championship is an international football competition in Central Asia for the member nations of the Central Asian Football Association (CAFA).