Reports by the AFP news agency suggest that the suspect was killed by law enforcement.
Some reports, however, suggest that the attacker is alive, but in critical condition, and receiving medical assistance at the moment.
One of the officers was injured in the stabbing attack and a large police and rescue force was deployed at the site of the incident. Marseille Mayor Benoit Payan has also gone to the site of the attack, Sputnik reported.
So far, there has been no official information about the identity of the assailant or anything to shed light on the causes behind the incident.
Interior Minister Gerald Darmanin later expressed his support for the officers, noting that to his knowledge, the perpetrator was a French national and not known to the police, as he had no criminal record.
The mayor of Marseille also welcomed the "very courageous actions" by law enforcement.
According to preliminary reports, the incident occurred this morning at the Old Port, with police opening fire at the perpetrator.