The Tigers took a deserved lead before the break when Allahyar Sayyadmanesh headed home Adama Traore’s near post corner.
Hayden Hackney levelled for the host with a composed finish from sub Isaiah Jones’ low center and Cameron Archer quickly slotted them into the lead when the Hull defense failed to deal with a long ball up the pitch.
Championship top scorer Chuba Akpom then slammed home his side’s third and his 29th goal of the campaign to secure the points against a shell-shocked Tigers.
This was a first defeat in six for Hull, who now host out-of-sorts Watford on Saturday.