Asadi found the back of the net at the Naghsh-e Jahan Stadium from the penalty spot in the first-half’s added time.
With four minutes remaining, Sepahan was reduced to 10 men after Farshad Ahmadzadeh received his yellow card.
In Tehran, Havadar was defeated against Aluminum 2-1, Malavan earned a 4-0 win over Foolad in Anzali and Sanat Naft was held to a 1-1 draw by Paykan in Abadan.
Thursday Fixture:
*Persepolis v Zob Ahan
*Nassaji v Gol Gohar