Zeighaminejad claimed a gold medal in the Men's 50m Freestyle - S10 Final with a time of 25.74 seconds.
Izadyar came second with 25.87 and the bronze medal went to Japan’s Akito Minai with 25.98.
Karimi also seized a silver in the Men’s 100-meter Backstroke.
He finished second with a time of 1:09.95 and the bronze medal went to Indonesian Rifky Yavianda with 1:03.55.
Zeighaminejad and Izadyar had claimed a gold and a silver medal in the Men's 100m Breaststroke - SB9 on Monday.
As the Asian Para Games returns to China for the second time following Guangzhou in 2010, nearly 3,100 athletes from 44 countries and regions are taking part across 22 sports and 564 events at the Hangzhou Asian Para Games, which runs through Oct 28.