Al Nassr defender Ali Lajami was sent off in the 17th minute for his reckless foul on Milad Sarlak.
Al Nassr of Saudi Arabia moved onto 13 points from five games with Persepolis five points behind and the result also means that Al Duhail has been eliminated after the Qatari side had knocked Istiklol out of the competition earlier in the day.
The Iranians can still take one of the three best runner-up spots available in the last 16 when it takes on Al Duhail in the final group game on December 5 in Tehran’s Azadi Stadium.