Sepahan is the only team from Iran who advanced from the group stage and will have to be at its best against an Al Hilal side determined to make up for losing in last season's final.
Sepahan had to work hard to confirm its knockout stage spot, with the Isfahan-based side finishing second in Group C, the-afc.com reported.
Its haul of 10 points saw them finishing five behind Saudi Arabia's Al Ittihad but it was enough for the 2007 runner-up to advance as one of the three best second-placed teams.
Al Hilal will be confident of its chances of not only advancing to the quarterfinals but also picking up a third AFC Champions League title.
It has been firing on all cylinders on the domestic and continental fronts and Sepahan can expect a tough test from one of Asian club football's giant.
The match will be held in Isfahan’s Naghsh-E-Jahan Stadium.