Both teams have endured indifferent starts domestically and will target a win to launch their continental campaigns on the front foot.
Al Ahli was denied three points by a late Al Nassr equalizer in the Saudi Pro League tie on Friday, with the stalemate taking the team to four points from three matches.
While Al Ahli has lost once in its last eight opening matches on the continental stage, it has failed to beat Iranian sides in the last three meetings.
Persepolis has found itself having to play catch up after just three matches into the Iran Pro League season, with the defending champion on five points - seven adrift of pacesetters Sepahan who has played a match more.
The head-to-head record, however, favors Persepolis who has won two of their four meetings with Al Ahli although the sides traded victories in the group stage of the AFC Champions League 2019.