Saeid Ahmadabbasi scored three goals and Salara Aqapour and Hossein Tayebi scored two goals each. Behrouz Azimi and Mehdi Karimi scored one goal.
Patrick Ruiz (twice) and Marvin Sandoval and Edgar Santizo scored for Guatemala.
Team Melli had started the campaign with a 7-1 win over Venezuela.
Iran will meet France on Sunday, while Guatemala play Venezuela.