In the match held in Ahvaz’s Ghadir Stadium, Farshid Baqeri was on target for visiting team Mes in the 26th minute, but Mes defender Mohammad Reza Mahdizadeh scored an own goal to level the score before the break.
Thievy Bifouma made it 2-1 for Esteghlal Khuzestan and Kaina Nunes scored the third goal in the 58th minute.
Behnam Barzay pulled a goal back with one minute remaining.
Elsewhere, Shams Azar and Havadar shared the spoils in a 1-1 draw in Qazvin and Chadormalu edged past Kheybar 1-0.
On Friday, Esteghlal will host Zob Ahan.