The car bombing took place in the Mir Ali area of North Waziristan, Khyber Pakhtunkhwa province, police officer Amjad Khanand said, adding that the injured were in critical condition, AP reported.
There was no immediate claim of responsibility but suspicion is likely to fall on the Pakistani Taliban, who operate out of Khyber Pakhtunkhwa and target security personnel.
Interior Minister Mohsin Naqvi condemned the attack and expressed his condolences to the families of the victims.
In a separate incident, a remote-controlled bomb struck a military convoy in Tank district, also in Khyber Pakhtunkhwa province. No casualties were reported.