Team Melli will meet Uzbekistan in Group A on Tuesday.
Iran has sent 150 male and female athletes to the Games in nine sports.
The tournament, which is seen as a precursor to the Deaflympics in Japan next year, is scheduled for December 1 to 8 in Kuala Lumpur.
Asia Pacific Deaf Games is a deaf multi-sport event established in 1984 which is held every four years in the Asia Pacific region. It is the successor to the "Far Eastern Deaf Football Championship" which was held in Taipei in 1983.