Kartal, 63, has penned an 18-month deal with the Iranian football team.
Persepolis parted ways with Spanish coach Juan Carlos Garrido in late December.
Now, the Iranian top-flight team is looking to remain a favorite in the domestic league.
The Reds are fourth in the 16-team table, five points adrift of leader Tractor.
Persepolis will host Tractor in Tehran’s Azadi Stadium on Sunday.