In Isfahan’s Naghsh-e Jahan Stadium, Reza Shekari opened the scoring for Sepahan in the 17th minute and Mohammad Karimi made it 2-0 from the penalty spot in the 76th minute.
Earlier in the day, 10-man Persepolis defeated Tractor in Tehran’s Azadi Stadium.
Soroush Rafiei was on target in the 11th minute and Giorgi Gvelesiani found the back of the net with a header in the 76th minute.
Persepolis was reduced to 10-man in the 45th minute after Mohammad Khodabandelou received a red card.
Foolad came from 2-0 behind to defeat Mes 3-2 in Rafsanjan.
Sepahan went top with 38 points, followed by Tractor and Foolad with 35 and 34 points, respectively.
Persepolis sits fourth with 33 points.