Mohammad Reza Azadi scored for Esteghlal in the 27th minute but Ahmad Reza Zendehrouh canceled out his goal in the dying moments of the match at the Sardar Azadegan Stadium in Qazvin.
Esteghlal winger Ramin Rezaeian scored the winning goal in the 95th minute to seal a 2-1 win for the Blues.
Esteghlal players Alireza and Saleh Hardani were sent off in the dying moments of the match.
Furthermore, Mes suffered a 1-0 home loss against Nassaji, Paykan came from 2-0 down to beat Foolad 3-2 in Tehran, and Sanat Naft beat Be’sat Kermanshah 2-0 in Abadan.