Defeat to Qatar on Thursday means Iran still have a bit of work to do if it wants to top the group, with Uzbekistan two points behind.
Head coach Amir Ghalenoei wasn't too worried by Thursday's defeat, with Iran having already sealed a fourth consecutive appearance at the FIFA World Cup in March.
"Several players missed the match through injury and this allowed us to try younger players. I think they did well and I am optimistic about the future," said Ghalenoei.
DPR Korea will go into the tie in search of their first win, with a late Kyrgyzstan goal denying them full points on Thursday.
It has been a difficult campaign for the East Asian side, with a return of just three points but victory over Iran will be a perfect way to sign off.