In the match, held at the Hisor Central Stadium in Hisor, Tajikistan, Amir Hossein Hosseinzadeh opened the scoring for Iran in the 59th minute.
Ali Alipour made the scoreboard 2-0 in the 89th and Mehdi Taremi scored Iran’s third goal in the dying moments of the match.
Iran, who had defeated Afghanistan 3-1 in their opening match, will meet Tajikistan on Thursday.
Group A participants are Uzbekistan, Kyrgyzstan, Turkmenistan, and Oman.