The match will be held in Tehran’s Shahr-E Qods Stadium.
Also, Al Muharraq of Bahrain will host Al Wasl in a meeting between two teams with perfect records.
Al Muharraq defeated Esteghlal 1-0 three weeks ago while UAE's Al Wasl beat Al Wehdat of Jordan 2-1.
With the sides set for a double header, victory for either team on Wednesday will take them within touching distance of a knockout stage spot.