With both having already confirmed their Round of 16 spots prior to the match, the win propelled Sepahan to the top of the standings on seven points - one ahead of Al Hussain that has a final fixture against Ahal of Turkmenistan on December 23.
Aria Yousefi gave the host a lead in 73rd minute in Isfahan’s Naghsh-e Jahan Stadium and Mohammad Askari doubled the advantage in the stoppage time.
Sepahan had lost to Al Hussain 1-0 on Matchday One.