Unlike Russia, the West, primarily the United States and its European allies, do not see President Bashar Assad as the country's legitimate leader, and support the Syrian militants which aim to oust the president.
Meanwhile, Russia has been assisting both the government and civilians of the war-torn country.
"If the next operation on the violent change of power in the Middle Eastern country is carried out, it will be disastrous not only for Syria, but will also become the most dangerous element in the destructive chain of events occurring in the region. The region may simply not endure one more black hole," Zakharova told Russia’s Komsomolskaya Pravda daily in an interview on Tuesday, Sputnik News reported.
According to her, the region might not just turn into a set of "lurid" states, but "explode" simultaneously as a whole.
"And what happens next? That’s exactly what the ISIL needs. Another area of chaos suits it over the odds. Therefore, we say that the most important task is to save the Syrian power structure," Zakharova stressed.
Syria has been in a state of civil war since 2011, with government forces countering several extremist groups, including the Islamic State in Iraq and the Levant (ISIL) and the Nusra Front.