Esteghlal moved two points clear at the top of group following their 1-0 win over Al Hilal two weeks ago.
The Iranian giant also drew 2-2 with Al Rayyan in its first match.
The Emirati side has drawn each of its first two games against Al Rayyan and Al Hilal, and will be seeking a first three points in front of home support.
After seeing off Uzbekistan’s Lokomotiv 2-0 in Isfahan, Zob Ahan is going to earn back-to-back home wins in Group B in Foolad Shahr Stadium.
Zob Ahan will face Al Wahda, in the knowledge that victory would put the team in a strong position at the midway point of the group stage.
Opponent Al Wahda has endured a disappointing start to its campaign, having lost its first two games, and will hope for an upturn of fortunes in Isfahan.