"The current deployment of US warships in the Caribbean Sea is nothing more than a blatant example of the reedition of the old colonizing approach," Padrino Lopez said in a statement commemorating Venezuela's Indigenous Resistance Day, which honors the struggle of indigenous peoples against colonization, Xinhua reported.
He accused Washington of seeking to "intimidate by force," adding that Venezuela's people and armed forces were "fully prepared and united" to defend national sovereignty.
"The battle we are fighting today is the same as 500 years ago: the defense of self-determination and the right to define our own destiny," he said.
The minister also criticized US attempts to subdue sovereign nations through "economic blockades, unilateral coercive sanctions, hybrid warfare and constant threats of military intervention."
Padrino Lopez said the Indigenous Resistance Day reaffirms Venezuela's "irrevocable anti-imperialist and anti-colonialist vocation."
The Venezuelan government has repeatedly denounced the recent US military deployment in the Caribbean as a threat to its sovereignty.