According to Hebrew-language media, the incident occurred as thousands of Haredi protesters gathered on Bar-Ilan Street in occupied Al-Quds to oppose forced conscription into the Israeli army.
Separately, Israeli emergency service Magen David Adom said an 18-year-old who had been trapped under the bus was pronounced dead at the scene.
Israeli police said they detained the bus driver and launched an investigation, without releasing his identity.
Video footage circulating online showed a bus driving directly into a dense crowd of ultra-Orthodox demonstrators at the intersection of Ohel Yehoshua and Shimgar streets.
Hebrew news outlet Ynet reported that around 10,000 Haredi Jews took part in the protest on Tuesday evening, rallying against compulsory enlistment in the Israeli army.
Several rabbis were present at the demonstration, which took place as the Knesset’s foreign affairs and security committee has yet to approve a proposed exemption bill backed by prime minister Benjamin Netanyahu’s coalition.
Meanwhile, protesters set fires along the street during the rally, escalating tensions as the demonstration continued.
The protest was organized by factions of the ultra-Orthodox community and rabbis who reject compulsory military service, with demonstrators chanting slogans warning that enforced conscription would destroy Haredi society.
One rabbi compared compulsory service in the Israeli army to what he described as the “Holocaust,” saying: “Even at that time, they could not imagine such a genocide. They did not believe it, and fortunately we know what happened.”
Initial reports said at least one Zionist protester was killed and three others were wounded, with their conditions unclear.
The bus driver, described as a Zionist immigrant, attempted to flee the scene but was later arrested by Israeli police.
In the aftermath, Israeli regime riot police used batons and water cannons to disperse the remaining demonstrators.
Separately, the dispute over mandatory military service has long exposed deep divisions within Israeli regime society, particularly over exemptions granted to ultra-Orthodox seminary students.
Many Israelis criticize the exemptions as an unfair burden on those who are forced to serve, while religious leaders argue that military service threatens the community’s religious identity.
Meanwhile, the conscription debate has intensified amid Israel’s heightened regional military adventurism, as the Israeli regime has recorded its highest military death toll in decades due to conflicts linked to Gaza, Lebanon, Syria, Yemen and Iran.