Syria's SANA news agency reported that the attack took place late on Sunday, and that one of the four "hostile targets" was downed in the Aqrabah suburb near the capital Damascus.
SANA did not further elaborate on the possible targets and casualties of the attack.
Meanwhile, the Syrian military repelled two drones flying over an airbase in the western city of Hama. Syrian forces also downed a third one over the city of Latakia.
Unconfirmed images on social media allegedly show Israeli aerial activity over the southern Lebanese port city of Sidon prior to the attack.
According to media reports, Israel last attacked Syria on November 20, with SANA reporting that Syrian air defense systems had fended off the Israeli airstrikes on the capital and its suburbs.
Tel Aviv also confirmed the attack, claiming to have struck dozens of what it described as Iranian and Syrian targets.
Israel has carried out hundreds of airstrikes in Syria, including in the Golan Heights, most of them against what the Tel Aviv regime claims to be the positions of pro-Syrian forces.